Description
AOD-9604 5mg — growth hormone fragment 176-191 for research
AOD-9604 5mg is the synthetic 176-191 fragment of human growth hormone, supplied as lyophilized powder at 99%+ purity for in vitro laboratory research.
Ships from within the USA. Supplied for laboratory research use only, and not for human or veterinary use.
About AOD-9604 5mg
AOD-9604 corresponds to the C-terminal 176-191 region of human growth hormone with an added tyrosine residue. The fragment is studied because it separates part of the parent hormone’s sequence from its receptor-binding domain: in the published in vitro work it does not engage the growth hormone receptor in the way the full-length hormone does, which makes it a tool for asking which observations require receptor binding and which do not.
Most of the literature is adipocyte culture and rodent tissue work. Purity by reverse-phase HPLC, identity by mass spectrometry.
Research applications of AOD-9604 5mg
- Adipocyte culture studies of lipolytic and lipogenic pathways
- Comparative work against full-length growth hormone in vitro
- Receptor-independent signaling investigations
- Fragment structure–activity relationship research
- Metabolic pathway readouts in cultured cell models
How this vial is supplied and handled
The vial arrives as a lyophilized cake or film in a sealed, stoppered vial. Keep it sealed and frozen at -20 °C until the day it is opened; brief periods at ambient temperature in transit are expected and do not compromise dry powder. Let the vial reach room temperature before breaking the seal so atmospheric moisture does not condense onto the cake.
Reconstitute by running the diluent slowly down the inside wall of the vial rather than onto the powder, and swirl rather than shake — peptides denature at an air-liquid interface. Hold the solution at 2–8 °C for short-term use, or aliquot and freeze for longer, and avoid repeated freeze-thaw cycles, the most common cause of a quiet loss of activity between one experiment and the next.
Ordering AOD-9604 5mg in the United States
AOD-9604 5mg ships to research laboratories throughout the USA, dispatched domestically from our US facility. Every parcel is tracked, and because the material stays inside the country there is no customs entry, no broker fee and no border hold between our shelf and your bench.
Shipping is calculated at checkout and orders over $200 USD ship free anywhere in the United States. Bulk pricing is available on larger quantities — email us before checkout and we will quote it.
Purity guarantee
If an independent laboratory tests this material and reports purity below the figure stated on its certificate, we refund the order and reimburse what the test cost you. Send the lot number printed on the vial along with the third-party report and we will settle it without argument.
The guarantee covers the analysis, not the outcome of your work. What AOD-9604 5mg does in your model is your experiment; what is in the vial is our responsibility.
Research use only
AOD-9604 5mg is supplied strictly for laboratory research carried out by qualified professionals. It is not a drug, a dietary supplement or a medical device.
It has not been evaluated or approved by the U.S. Food and Drug Administration for any use. It is not for human or veterinary consumption, for clinical investigation in human subjects, or for therapeutic, diagnostic or cosmetic application of any kind.
We do not provide dosing, administration or protocol advice, and we cannot answer questions about use in people or animals. By ordering, you confirm that you are acquiring this material for lawful research in a controlled laboratory setting and that you will not redistribute it for any other purpose.
Compound identity and specification
Identity data for AOD-9604, published so the material can be checked against an independent record rather than taken on trust. The formula, mass and registry number below are verified against PubChem and can be looked up directly.
| Compound | AOD-9604 |
|---|---|
| Sequence | Tyr followed by the human growth hormone 177-191 fragment |
| Molecular formula | C78H123N23O23S2 |
| Molecular mass | 1815.1 g/mol |
| CAS registry number | 221231-10-3 |
| PubChem | CID 71300630 |
| Vial content | 5 mg |
| Physical form | Lyophilized powder in a sealed vial |
| Analysis | Third-party HPLC where a report has been commissioned; see the certificates of analysis page |
| Supplied for | Laboratory research use only |
Analytical note — AOD-9604. A 16-residue construct: a tyrosine added to the hGH(177-191) fragment, which is why the tyrosine is there at all – it gives the molecule a 280 nm chromophore the bare fragment would lack. It contains a disulfide bridge, so a reduced form of about 2 Da higher mass is a possible related substance.
Identity references The molecular formula, molecular mass and CAS registry number above are taken from the PubChem record linked in the table, not from a supplier datasheet, so every figure can be checked against an independent source in one click. Sequences are given as reported in the peptide literature, in the one-letter or three-letter convention as appropriate, with any non-standard residue named in full. Where a compound exists in more than one form — a free peptide and a metal complex, a fragment and its parent protein, a modified and an unmodified analog — the form supplied is the one identified here, and the mass on the certificate of analysis is what distinguishes it.
Research Literature
Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.
- Heffernan M, et al. Endocrinology. 2001;142(12):5182-5189. In wild-type and beta3-adrenergic receptor knockout mice, measured beta3-AR mRNA expression, establishing receptor dependency. Source · PMID 11713213
- Ng FM, et al. Horm Res. 2000;53(6):274-278. In a Zucker rat model, characterized ex vivo receptor-pathway activity; see the linked record for methods and endpoints. Source · PMID 11146367
Literature notes: Papers concerning the related analog AOD-9401 are sometimes miscited as AOD-9604 work; the references above concern AOD-9604 specifically.
Every certificate of analysis we hold is collected on the certificates of analysis page. Where a lot has not been independently tested we do not claim that it has.
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