Description
Kisspeptin-10 5mg — KISS1R agonist decapeptide for research
Kisspeptin-10 5mg is the C-terminal decapeptide fragment of kisspeptin, supplied as lyophilized powder at 99%+ purity for in vitro receptor and neuroendocrine research.
Ships from within the USA. Supplied for laboratory research use only, and not for human or veterinary use.
About Kisspeptin-10 5mg
Kisspeptin-10 is the shortest fragment of the KISS1 gene product that retains full activity at KISS1R (GPR54), a Gαq-coupled receptor. In laboratory work it is the standard agonist for that receptor system: calcium mobilization and inositol phosphate accumulation in transfected lines, and hypothalamic explant and neuronal culture studies of GnRH neuron signaling.
Purity by reverse-phase HPLC, identity by mass spectrometry. The peptide is comparatively short-lived in the presence of peptidases, which is a design consideration for longer in vitro time-courses.
Research applications of Kisspeptin-10 5mg
- Calcium mobilization assays in KISS1R-expressing cell lines
- Inositol phosphate accumulation and Gαq signaling readouts
- Hypothalamic explant and neuronal culture protocols
- Receptor binding and displacement studies in vitro
- Peptide stability and degradation kinetics research
How this vial is supplied and handled
The vial arrives as a lyophilized cake or film in a sealed, stoppered vial. Keep it sealed and frozen at -20 °C until the day it is opened; brief periods at ambient temperature in transit are expected and do not compromise dry powder. Let the vial reach room temperature before breaking the seal so atmospheric moisture does not condense onto the cake.
Reconstitute by running the diluent slowly down the inside wall of the vial rather than onto the powder, and swirl rather than shake — peptides denature at an air-liquid interface. Hold the solution at 2–8 °C for short-term use, or aliquot and freeze for longer, and avoid repeated freeze-thaw cycles, the most common cause of a quiet loss of activity between one experiment and the next.
Ordering KISSPEPTIN-10 5mg in the United States
KISSPEPTIN-10 5mg ships to research laboratories throughout the USA, dispatched domestically from our US facility. Every parcel is tracked, and because the material stays inside the country there is no customs entry, no broker fee and no border hold between our shelf and your bench.
Shipping is calculated at checkout and orders over $200 USD ship free anywhere in the United States. Bulk pricing is available on larger quantities — email us before checkout and we will quote it.
Purity guarantee
If an independent laboratory tests this material and reports purity below the figure stated on its certificate, we refund the order and reimburse what the test cost you. Send the lot number printed on the vial along with the third-party report and we will settle it without argument.
The guarantee covers the analysis, not the outcome of your work. What Kisspeptin-10 5mg does in your model is your experiment; what is in the vial is our responsibility.
Research use only
Kisspeptin-10 5mg is supplied strictly for laboratory research carried out by qualified professionals. It is not a drug, a dietary supplement or a medical device.
It has not been evaluated or approved by the U.S. Food and Drug Administration for any use. It is not for human or veterinary consumption, for clinical investigation in human subjects, or for therapeutic, diagnostic or cosmetic application of any kind.
We do not provide dosing, administration or protocol advice, and we cannot answer questions about use in people or animals. By ordering, you confirm that you are acquiring this material for lawful research in a controlled laboratory setting and that you will not redistribute it for any other purpose.
Compound identity and specification
Identity data for Kisspeptin-10, published so the material can be checked against an independent record rather than taken on trust. The formula, mass and registry number below are verified against PubChem and can be looked up directly.
| Compound | Kisspeptin-10 |
|---|---|
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF amide) |
| Molecular formula | C63H83N17O14 |
| Molecular mass | 1302.4 g/mol |
| CAS registry number | 374675-21-5 |
| PubChem | CID 25240297 |
| Vial content | 5 mg |
| Physical form | Lyophilized powder in a sealed vial |
| Analysis | Third-party HPLC where a report has been commissioned; see the certificates of analysis page |
| Supplied for | Laboratory research use only |
Analytical note — Kisspeptin-10. The C-terminus is amidated, one Da lighter than the corresponding free acid, and the free acid is a known synthesis by-product. Tryptophan, tyrosine and two phenylalanines make it strongly ultraviolet-active at 280 nm.
Identity references The molecular formula, molecular mass and CAS registry number above are taken from the PubChem record linked in the table, not from a supplier datasheet, so every figure can be checked against an independent source in one click. Sequences are given as reported in the peptide literature, in the one-letter or three-letter convention as appropriate, with any non-standard residue named in full. Where a compound exists in more than one form — a free peptide and a metal complex, a fragment and its parent protein, a modified and an unmodified analog — the form supplied is the one identified here, and the mass on the certificate of analysis is what distinguishes it.
Research Literature
Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.
- Kotani M, et al. J Biol Chem. 2001;276(37):34631-34636. In transfected cells, measured low-nanomolar binding affinity at GPR54 with phosphoinositide hydrolysis, calcium mobilisation and MAPK phosphorylation. Source · PMID 11457843
- Han SK, et al. J Neurosci. 2005;25(49):11349-11356. In mouse brain slices, measured depolarisation of GnRH neurons and GPR54/KiSS-1 mRNA expression across postnatal ages. Source · PMID 16339030
- Liu X, et al. Endocrinology. 2008;149(9):4605-4614. In mouse GnRH neurons, measured membrane potential, firing rate, intracellular calcium and ion-channel contributions, attenuated by PLC/IP3 blockade. Source · PMID 18483150
Every certificate of analysis we hold is collected on the certificates of analysis page. Where a lot has not been independently tested we do not claim that it has.
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