SS-31 Peptide 10mg

Description

SS-31 peptide 10mg — mitochondria-targeted research tetrapeptide

SS-31 peptide 10mg, also written elamipretide, is a synthetic aromatic-cationic tetrapeptide supplied as lyophilized powder at 99%+ purity for in vitro mitochondrial research.

Ships from within the USA. Supplied for laboratory research use only, and not for human or veterinary use.

About SS-31 10mg

SS-31 belongs to the Szeto-Schiller series of aromatic-cationic peptides, which localize to the inner mitochondrial membrane through an interaction with cardiolipin rather than through a membrane potential gradient. That distinction is the reason the compound is used as a tool: it concentrates at the membrane in both polarized and depolarized mitochondria, which most cationic probes do not.

Published in vitro work covers mitochondrial respiration and ATP production in isolated mitochondria and permeabilized cells, reactive oxygen species measurement, and cristae morphology by electron microscopy.

Research applications of SS-31 10mg

• Oxygen consumption and respiratory capacity measurement in isolated mitochondria
• ATP production assays in permeabilized cell preparations
• Reactive oxygen species quantification in culture
• Cardiolipin interaction and membrane binding studies
• Cristae morphology work by electron microscopy

How this vial is supplied and handled

The vial arrives as a lyophilized cake or film in a sealed, stoppered vial. Keep it sealed and frozen at -20 °C until the day it is opened; brief periods at ambient temperature in transit are expected and do not compromise dry powder. Let the vial reach room temperature before breaking the seal so atmospheric moisture does not condense onto the cake.

Reconstitute by running the diluent slowly down the inside wall of the vial rather than onto the powder, and swirl rather than shake — peptides denature at an air-liquid interface. Hold the solution at 2–8 °C for short-term use, or aliquot and freeze for longer, and avoid repeated freeze-thaw cycles, the most common cause of a quiet loss of activity between one experiment and the next.

Ordering SS-31 10mg in the United States

SS-31 10mg ships to research laboratories throughout the USA, dispatched domestically from our US facility. Every parcel is tracked, and because the material stays inside the country there is no customs entry, no broker fee and no border hold between our shelf and your bench.

Shipping is calculated at checkout and orders over $200 USD ship free anywhere in the United States. Bulk pricing is available on larger quantities — email us before checkout and we will quote it.

Purity guarantee

If an independent laboratory tests this material and reports purity below the figure stated on its certificate, we refund the order and reimburse what the test cost you. Send the lot number printed on the vial along with the third-party report and we will settle it without argument.

The guarantee covers the analysis, not the outcome of your work. What SS-31 10mg does in your model is your experiment; what is in the vial is our responsibility.

Research use only

SS-31 10mg is supplied strictly for laboratory research carried out by qualified professionals. It is not a drug, a dietary supplement or a medical device.

It has not been evaluated or approved by the U.S. Food and Drug Administration for any use. It is not for human or veterinary consumption, for clinical investigation in human subjects, or for therapeutic, diagnostic or cosmetic application of any kind.

We do not provide dosing, administration or protocol advice, and we cannot answer questions about use in people or animals. By ordering, you confirm that you are acquiring this material for lawful research in a controlled laboratory setting and that you will not redistribute it for any other purpose.

Compound identity and specification

Identity data for SS-31 (elamipretide), published so the material can be checked against an independent record rather than taken on trust. The formula, mass and registry number below are verified against PubChem and can be looked up directly.

Analytical note — SS-31 (elamipretide). A four-residue peptide containing a D-arginine and 2,6-dimethyltyrosine, a non-standard residue. It is strongly basic and small, so retention depends heavily on ion-pairing additive, and the non-standard residues mean routine amino-acid analysis will not match a standard reference table.

Identity references The molecular formula, molecular mass and CAS registry number above are taken from the PubChem record linked in the table, not from a supplier datasheet, so every figure can be checked against an independent source in one click. Sequences are given as reported in the peptide literature, in the one-letter or three-letter convention as appropriate, with any non-standard residue named in full. Where a compound exists in more than one form — a free peptide and a metal complex, a fragment and its parent protein, a modified and an unmodified analog — the form supplied is the one identified here, and the mass on the certificate of analysis is what distinguishes it.

Research Literature

Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.

• Zhao K, et al. J Biol Chem. 2004;279(33):34682-34690. In neuronal cells and isolated mitochondria, measured intracellular ROS, mitochondrial swelling and membrane depolarisation at nanomolar concentrations. Source · PMID 15178689
• Birk AV, et al. J Am Soc Nephrol. 2013;24(8):1250-1261. In ischemic rat kidney, measured high-affinity cardiolipin binding, inhibition of cytochrome c peroxidase activity and cristae ultrastructure. Source · PMID 23813215
• Mitchell W, et al. J Biol Chem. 2020;295(21):7452-7469. In model membranes and isolated mitochondria, measured interfacial partitioning as a function of bilayer surface charge, lipid packing and surface electrostatics. Source · PMID 32273339

Every certificate of analysis we hold is collected on the certificates of analysis page. Where a lot has not been independently tested we do not claim that it has.

Related Research Compounds

Browse more compounds in Mitochondrial & Cellular Compounds, or view the full research peptide catalog.

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