Description
PT-141 10mg — melanocortin receptor agonist for laboratory research
PT-141 10mg, also written bremelanotide, is a synthetic cyclic heptapeptide supplied as lyophilized powder at 99%+ purity for in vitro receptor pharmacology research.
Ships from within the USA. Supplied for laboratory research use only, and not for human or veterinary use.
About PT-141 10mg
PT-141 is a melanocortin receptor agonist derived structurally from the melanotan series, with activity reported at MC1R, MC3R and MC4R in receptor binding and functional assays. Its use in the laboratory is as a tool for melanocortin receptor pharmacology: subtype selectivity profiling, cAMP accumulation in transfected lines, and comparative work against other agonists in the same family.
We describe the compound in terms of receptor pharmacology because that is what the in vitro data supports. We do not discuss use in people, and we cannot answer questions framed that way.
Research applications of PT-141 10mg
- Melanocortin receptor subtype selectivity profiling
- cAMP accumulation assays in MC1R, MC3R and MC4R transfected lines
- Receptor binding and displacement studies in vitro
- Comparative pharmacology across the melanocortin agonist series
- Structure–activity relationship work on cyclic peptides
How this vial is supplied and handled
The vial arrives as a lyophilized cake or film in a sealed, stoppered vial. Keep it sealed and frozen at -20 °C until the day it is opened; brief periods at ambient temperature in transit are expected and do not compromise dry powder. Let the vial reach room temperature before breaking the seal so atmospheric moisture does not condense onto the cake.
Reconstitute by running the diluent slowly down the inside wall of the vial rather than onto the powder, and swirl rather than shake — peptides denature at an air-liquid interface. Hold the solution at 2–8 °C for short-term use, or aliquot and freeze for longer, and avoid repeated freeze-thaw cycles, the most common cause of a quiet loss of activity between one experiment and the next.
Ordering PT-141 10mg in the United States
PT-141 10mg ships to research laboratories throughout the USA, dispatched domestically from our US facility. Every parcel is tracked, and because the material stays inside the country there is no customs entry, no broker fee and no border hold between our shelf and your bench.
Shipping is calculated at checkout and orders over $200 USD ship free anywhere in the United States. Bulk pricing is available on larger quantities — email us before checkout and we will quote it.
Purity guarantee
If an independent laboratory tests this material and reports purity below the figure stated on its certificate, we refund the order and reimburse what the test cost you. Send the lot number printed on the vial along with the third-party report and we will settle it without argument.
The guarantee covers the analysis, not the outcome of your work. What PT-141 10mg does in your model is your experiment; what is in the vial is our responsibility.
Research use only
PT-141 10mg is supplied strictly for laboratory research carried out by qualified professionals. It is not a drug, a dietary supplement or a medical device.
It has not been evaluated or approved by the U.S. Food and Drug Administration for any use. It is not for human or veterinary consumption, for clinical investigation in human subjects, or for therapeutic, diagnostic or cosmetic application of any kind.
We do not provide dosing, administration or protocol advice, and we cannot answer questions about use in people or animals. By ordering, you confirm that you are acquiring this material for lawful research in a controlled laboratory setting and that you will not redistribute it for any other purpose.
Compound identity and specification
Identity data for PT-141 (bremelanotide), published so the material can be checked against an independent record rather than taken on trust. The formula, mass and registry number below are verified against PubChem and can be looked up directly.
| Compound | PT-141 (bremelanotide) |
|---|---|
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Molecular formula | C50H68N14O10 |
| Molecular mass | 1025.2 g/mol |
| CAS registry number | 189691-06-3 |
| PubChem | CID 9941379 |
| Vial content | 10 mg |
| Physical form | Lyophilized powder in a sealed vial |
| Analysis | Third-party HPLC on this vial: ILS Laboratories COA-2026-VMNVSK (99.83% purity, 10.32 mg net peptide content) |
| Supplied for | Laboratory research use only |
Analytical note — PT-141 (bremelanotide). A cyclic lactam peptide, and its ring is what distinguishes it analytically from the linear alternatives. It differs from Melanotan II by one atom of the C-terminus: a free acid here against an amide there, about 1 Da apart, which is why a rounded mass on a certificate cannot tell them apart.
Identity references The molecular formula, molecular mass and CAS registry number above are taken from the PubChem record linked in the table, not from a supplier datasheet, so every figure can be checked against an independent source in one click. Sequences are given as reported in the peptide literature, in the one-letter or three-letter convention as appropriate, with any non-standard residue named in full. Where a compound exists in more than one form — a free peptide and a metal complex, a fragment and its parent protein, a modified and an unmodified analog — the form supplied is the one identified here, and the mass on the certificate of analysis is what distinguishes it.
Research Literature
Peer-reviewed studies involving this compound and its class. All findings listed are from in vitro, cell culture or animal models and are provided for scientific reference only. This product is supplied for laboratory research and is not approved for human consumption, clinical, or veterinary use.
- Suzuki S, et al. Anticancer Res. 2024;44(9):3875-3883. In human glioblastoma cell lines, measured survivin protein expression and cell death, blocked by melanocortin receptor antagonists and by survivin overexpression. Source · PMID 39197897
- Yuan XC, Tao YX Biomolecules. 2022;12(10):1407. Review cataloguing ligand pharmacology across the five melanocortin receptors, including approved melanocortin-receptor agonists. Source · PMID 36291616
Literature notes: Most primary literature on this compound reports clinical endpoints and is outside the scope of this reference list.
Related Research Compounds
Browse more compounds in Melanocortin Peptides, or view the full research peptide catalog.
Background on the compound: PT-141, melanocortin selectivity and the lactam bridge — receptor subtype profile, how it differs from melanotan-II, and what to check on the certificate.
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